Although several pro-fibrotic cytokines such as TGF-β and PDGF, have been found to play essential roles in the process of fibrosis, systemic inhibition of these cytokines, for example TGF-β, could also impair tumor suppression or cause chronic inflammation because their critical function in normal homeostasis (Dewidar et al. 2019; Friedman et al. 2013). The gene discussed is TGFB1; the disease is neoplasm.