The occurrence of liver fibrosis is accompanied by chronic inflammation, during which the levels of pro-inflammatory cytokines are upregulated and released to activate hepatic stellate cells (HSCs), among which transforming growth factor-β (TGF-β) and platelet-derived growth factor (PDGF) are the most potent pro-fibrotic cytokines (Bonner 2004; Meng et al. 2016; Stewart et al. 2018). The gene discussed is TGFB1; the disease is Hepatic fibrosis.