In addition, the content of hydroxyproline in liver tissue and the serum level of alanine aminotransferase (ALT), which indicate the severity of liver fibrosis and impaired liver function, respectively, were decreased markedly in the IgG78-DM1 treatment group, indicating that liver fibrosis was inhibited while liver function was improved (Fig. 5F, G). Here, GPT is linked to Hepatic fibrosis.