For instance, the most susceptible CD8+ TEM had 34 M gene mRNAs at 0 h.p.i. and no M2 transcripts; while a total of 47 M gene mRNAs with M2 transcripts accounted for only 8.5% at 16 h.p.i. The above results indicates that H1N1 presents impaired splicing efficiency after infection of human CD8+ T cells (Figure 4B). This evidence concerns the gene CD8A and infection.