FLG and Alzheimer disease: AD is a disease characterized by skin barrier dysfunction whose causes aremultifactorial and include FLG mutations, physical damagefrom scratching, and microbial dysbiosis.1 Disruptions in skin barrier function result in increased permeabilityand TEWL, reduced water composition, and altered lipid composition.1,49, -51 Our results suggest that the factors within the diaper region mayboth protect against development of skin barrier dysfunction and alsoameliorate the consequences of skin barrier dysfunction.