Fraser et al. (2013) demonstrated the presence of LRRK2 in urinary exosomes, small endosomal-derived vesicles released from cells to the periphery. Intriguingly, G2019S carriers with PD displayed higher pS1292 to the total LRRK2 ratio in urinary exosomes compared to non-carriers and even asymptomatic G2019S carriers, indicating the potential for risk prediction (Fraser et al., 2016). The gene discussed is LRRK2; the disease is Parkinson disease.