We observed that CAR (GPC3) T cells killed Hep3B tumor cells efficiently but inducible PD-L1 expression was found in the Hep3B cells co-cultured with CAR (GPC3) T cells rather than control CAR (CD19) T cells (Figure 5F), which may allow cancers to evade the host immune system. This evidence concerns the gene CD274 and neoplasm.