Such patients were characterized by early-onset CVID associated with autoimmunity, reduction in circulating B-cells, adrenocorticotropic hormone deficiency, hair and/or nail disorders and occasional other pituitary hormone deficiencies.[36, 37] However, we found no abnormal immunological laboratory findings, although we followed the newborn with NFKB2 mutation in our cohort until the age of 3. This evidence concerns the gene NFKB2 and Abnormal nail morphology.