However, recent studies have suggested that NEBC could be associated with worse long-term outcomes.[6] In addition, a large retrospective study by Zhang et al. reported a higher probability of local recurrence and poorer OS for NEBCs.[21] In the available literature, the prognostic factors affecting survival are indicated as disease stage, number of lymph-node metastases, and ER and PR status.[22] In the present study, age, grade, metastatic status, number of lymph nodes and molecular type were identified as prognostic factors that significantly affect survival in both groups. The gene discussed is ESR1; the disease is metastatic malignant neoplasm in the lymph nodes.