Figure 2 indicates that the patients with ATTR V30M appear to consist of two groups; one with an age of onset above 40 years in which the increased brain amyloid deposition (Z-score > 2) is evenly distributed between the different regions, and another group with a disease onset below the age of 40 in which the amyloid distribution is noted especially in the cerebellum. The gene discussed is TTR; the disease is amyloidosis.