MAPT and tauopathy: Tauopathies can be sporadic or inherited when caused by mutations in the MAPT gene encoding the microtubule-associated protein tau (Rohrer et al., 2009; Benussi et al., 2015), but the molecular mechanisms leading to neuronal toxicity and death, and therefore potential therapeutic targets, are still not fully understood (Gotz et al., 2013; Panza et al., 2016; Congdon and Sigurdsson, 2018; Medina, 2018).