MAPT and tauopathy: In addition, we focused on the tau-P301L neuronal model as a representative of tauopathy pathology associated with accumulation of insoluble species in the brain (oligomers, aggregates, and higher order fibrils and tangles) (Nacharaju et al., 1999; Barghorn et al., 2000; Ramsden et al., 2005; Kimura et al., 2010).