Zerumbone has been shown to induce anti-inflammatory properties in microglial cells (a type of macrophage cell) by inhibiting the mitogen-activated protein kinase (MAPK) pathway, proposing the role of zerumbone as a neuroprotector, besides zerumbone is also reported to have anticancer, pro-inflammatory, and chemoprevention against various cancers (19). Here, WNK2 is linked to cancer.