Moreover, expression of CCR5 (ligands CCL3, CCL4, and CCL5), CCR4 (ligands CCL17 and CCL22), and CCR3 (ligands eotaxin and eotaxin-2) on different immune cells is associated with the progress of inflammation in SLE (11, 12). This evidence concerns the gene CCR4 and systemic lupus erythematosus.