To determine the FGFs expression patterns in placentas of GDM during gestation, first, the placental RNA levels of six representative FGF members (Fgf1, Fgf4, Fgf7, Fgf8, Fgf9 and Fgf21) were examined using 18 placentas of GDM patients and 19 placentas of normal patients. Here, FGF8 is linked to gestational diabetes.