Although not studied clinically and not in the context of HRVs, the downregulation of ICAM-1 by ICAM-1 siRNA on human bronchial epithelial cells resulted in alteration of influenza virus copy numbers, suggesting the crucial role of ICAM-1 in this viral infection (Othumpangat et al. 2016). This evidence concerns the gene ICAM1 and viral infectious disease.