On the contrary, several studies have questioned the potential role of sICAM-1 as an antagonist for ICAM-1/LFA-1-induced inflammation in asthma, primarily because sICAM-1 is also known for its pro-inflammatory properties which play a significant role in diseases like systemic inflammatory response syndrome and gram-negative pneumonia (Mendez et al. 2011; de Pablo et al. 2013). Here, ICAM1 is linked to asthma.