For instance, the addition of M5 protein that adheres explicitly to ICAM-1 and ICAM-4, or siRNA targeting ICAM-1 decreased infection of cultured THP-1 (a human monocytic leukemia cell line) and murine peritoneal macrophages by Mycobacterium tuberculosis (Bhalla et al. 2015). This evidence concerns the gene ICAM1 and monocytic leukemia.