Although most attention has been on HRV, evidence indicates that ICAM-1 also serves as an adhesion molecule for Haemophilus influenzae (NTHi, via bacterial P5 fimbriae), which is the main bacterial pathogen in COPD, again especially in AECOPD (Sethi and Murphy 2008). The gene discussed is ICAM1; the disease is chronic obstructive pulmonary disease.