HAVCR2 and melanoma: To determine whether Tim-3 on DCs regulates the trogocytosis of CD8+ TILs, we generated Havcr2fl/fl E8icre and Havcr2fl/fl Cd11ccre mice with Tim-3 deletion in CD8+ T cells or CD11c+ cells, respectively, and evaluated CD8+ T cell trogocytosis in YUMMER 1.7 melanoma (Figure 7).