ANO1 and ischemic stroke: Our analysis showed that, while genetically proxied TMEM16A activity was not associated with increased risk of ischemic stroke (OR per allele associated with increased TMEM16A expression, 1.01; 95% CI, 0.99–1.03; P = 0.25), increased genetically proxied TMEM16A expression associated with worse functional outcome (score 3–6 of the modified Rankin Scale) at 60–190 days following ischemic stroke (OR, 1.13; 95% CI, 1.03–1.25; P = 0.01).