ANO1 and ischemic stroke: To investigate this in humans, we identified a genetic proxy for TMEM16A activity (Table 1) and applied this in a Mendelian randomization analysis (51) to explore its association with (a) the risk of developing ischemic stroke (using the MEGASTROKE genetic association study; ref. 52) and (b) recovery after ischemic stroke (using the GISCOME study; ref. 53).