In comparison to data associated with the analysis of other tumor regions, necrotic regions showed decreased RNA levels for the expression of GBM antigens (such as IL13RA2 and MAGEB2), DC markers (such as LILRA4), as well as the expression of immune stimulatory processes, including MHC, IFN, IL-12, TNF, and ICOS (Supplemental Figure 1). The gene discussed is ICOS; the disease is neoplasm.