Therefore, the aim of this study was to define the specific effects of iron deficiency on host mediators of H. pylori–induced gastric inflammation and injury in 2 well-defined, independent, genetically inbred murine models of H. pylori infection: wild-type C57BL/6 mice and transgenic Friend virus B NIH FVB/N-Tg(Ins1-GAS) (FVB/N INS-GAS) mice that overexpress gastrin and are genetically predisposed to develop gastric dysplasia (21, 22). This evidence concerns the gene GAST and Iron deficiency anemia.