In contrast to investigations in DM1 mice, exercise-mediated AMPK activation in DM1 patients failed to increase cytosolic MBNL1 content, reduce MBNL1/CUG-positive myonuclei, or alter the DM1-associated transcriptome (Figure 3 and Figure 4C). Here, MBNL1 is linked to myotonic dystrophy type 1.