MicroRNA is a small non-coding RNA molecule playing a crucial role in the biological process of cell cycle regulation, proliferation, apoptosis, and differentiation.26 It is predominantly through directly binding to the 3 ́UTR of the target gene mRNA and inducing translational inhibition or post-transcriptional degradation.27,28 For the purpose of further exploring the upstream regulatory mechanism of MT1X, we utilized bioinformatics to analyze miRNAs in GSE142699 to obtain miR-376a-3p, which had targeted binding sites with MT1X and was obviously downregulated in AML. Here, MT1X is linked to acute myeloid leukemia.