Salivary S100A8, S100A12, and MMP‐8 concentrations were associated with periodontitis, ABL, the number of periodontal pockets with PPD 4 to 5 mm, and especially the number of periodontal pockets with PPD ≥ 6 mm (OR for 10‐fold increase in S100A8: 4.22; 95% CI, 2.15 to 8.30; P < 0.001). Here, S100A8 is linked to periodontitis.