Consistent with this reduction in inflammation, obese/T2D + OF mice showed a markedly decreased expression of several chemokines compared to obese/T2D control mice, including keratinocyte-derived chemokine (KC; CXCL1), monocyte chemoattractant protein 1 (MCP-1; CCL2), monokine induced by interferon-γ (IFN-γ) (MIG; CXCL9), IFN-γ-induced protein 10 kDa (IP-10; CXCL10), and regulated upon activation, normal T cell expressed and presumably secreted (RANTES; CCL5) (Fig. 3D to H). Here, CXCL1 is linked to type 2 diabetes mellitus.