TRIM63 and chronic kidney disease: On the one hand, CKD significantly modifies the composition and functions of the GM and contributes to dysbiosis in humans, while on the other hand, GM could lead to CKD onset and progression through the production of proinflammatory metabolites, such as the well known uremic toxin indoxyl‐sulfate.[37, 38] In our study, the effects of the PR‐diet on the serum concentrations of IPA differed according to the presence of IRF.