In human subjects, upregulation of LPA2 and downregulation of LPA1 has been demonstrated in colon cancer,43 and upregulation of LPA1 and LPA3 and association of LPA2 and LPA6 expression with differentiation has been demonstrated in hepatocellular carcinoma.44, 45. The gene discussed is LPAR6; the disease is malignant colon neoplasm.