Employing processes used to identify genes associated with ivacaftor responsiveness (51), we found that unlike HC PBMCs and plasma-cultured counterparts, the innate immune pathway was downregulated in CFTR-mutated PBMCs and in CF plasma-cultured healthy PBMCs and THP-1 monocytes (Figure 2D and Figure 6D). This evidence concerns the gene CFTR and cystic fibrosis.