CFTR and cystic fibrosis: We identified CFTR-related immune suppression in each trio subgroup through transcriptomic profiling using 3 cellular models: (i) a PBMC model; (ii) a plasma model, where the donors’ PBMCs act as reporters of the immune microenvironment and compromised immune/inflammatory conditions in individuals with CF; and (iii) a THP-1 cell model, where THP-1 cells are incubated with plasma, replicating the effects of the immune microenvironment on monocyte and macrophage function.