We estimated a significantly higher abundance of 2 out of 5 lymphoid cell subsets (total T cells and CD4+ T cells) and a significantly lower abundance of all 5 myeloid cell subsets (monocytes, macrophages, activated monocytes, activated macrophages, and DCs) in cells incubated with CF proband plasma than in cells incubated with HC plasma (Figure 4A and Supplemental Figure 5A). Here, CD4 is linked to cystic fibrosis.