CXCL2 and neoplasm: As expected, blockade of either CSF1R (in CAFs), or MIP2 (in CAFs), or CXCR2 (in macrophages) enhanced the IL-12/IL-10 expression ratio in the latter (Figure 7, A and B), which was further corroborated with enhanced cytotoxicity against tumor cells (Figure 7, C and D).