CXCL2 and neoplasm: Our evidence suggests that CSF1R located in CAFs, once activated by CSF1 (secreted by tumor cells or tumor endothelium), leads to MIP2 secretion that subsequently signals through the CXCR2 receptor located on macrophages and enhances the IL-10/IL-12 ratio (which is functionally related with M2 polarization) (Figure 8).