Pleural and tumor levels of MPE-related proinflammatory mediators (IL-6; VEGF; monocyte chemoattractant protein-1, MCP-1; TNFA; secreted phosphoprotein 1, OPN; and macrophage inflammatory protein 2, MIP2) were not affected by macrophage CSF1R ablation (Supplemental Figure 5, A–D). Here, SPP1 is linked to neoplasm.