CASP3 and neoplasm: Immunohistochemical (IHC) analysis of NCC_CDS1_X1_C1 tumor explants further validated that WEE1 inhibition increased DNA damage and enhanced apoptosis, as demonstrated by increased γH2AX and cleaved caspase-3 expression in mice treated with adavosertib compared with vehicle control (Figure 4, G and H).