Besides, several regulatory ECM proteins were downregulated, including lysosomal cysteine proteinases (CTSA, CTSB, CTSC, CTSD, CTSH, CTSK, and CTSL), proteinase inhibitors (CSTB, SERPINB12, SERPINB5, and SERPINB8), and secreted factors (FLG2, IL1RN, S100A1, S100A11, S100A14, and S100A16) in scleroderma mouse skin (Figure S3b and Table S3, Supporting Information). The gene discussed is CTSD; the disease is scleroderma.