The expressions of endothelial cell adhesion markers (platelet and endothelial cell adhesion molecule 1 [CD31] and integrin subunit beta 1 [ITGB1]) and angiogenesis‐associated matrix metalloproteinase nine (MMP9) were upregulated in the treatment group (Figure 4g), indicating that the EM organoids can promote skin angiogenesis in scleroderma mice. This evidence concerns the gene MMP9 and scleroderma.