FN1 and scleroderma: The core ECM proteins, including 9 collagens, 6 proteoglycans, and 39 glycoproteins were upregulated in scleroderma mouse skin, according to the Matrisome database (Figure S3a and Table S3, Supporting Information).[10] Among them, epithelial–mesenchymal transition (EMT) associated proteins including laminins, fibronectin 1, and type IV/VI collagens were also found upregulated (Figure 1g).