PECAM1 and scleroderma: The expressions of endothelial cell adhesion markers (platelet and endothelial cell adhesion molecule 1 [CD31] and integrin subunit beta 1 [ITGB1]) and angiogenesis‐associated matrix metalloproteinase nine (MMP9) were upregulated in the treatment group (Figure 4g), indicating that the EM organoids can promote skin angiogenesis in scleroderma mice.