2015). Therefore, the loss of Adycap1r1 is important to highlight in arsenic-induced T2D. Overall, our data reveal that, while there are some shared gene expression changes in iAsIII and MAsIII treated beta cells, iAsIII and MAsIII exert some unique effects on beta cell processes. Specifically, while miR-29a-mediated regulation of insulin secretion pathways appears to be prominent after iAsIII treatment, miR-29a-mediated regulation of beta cell survival and maintenance is likely to be of greater relevance in the context of MAsIII treatment. The gene discussed is INS; the disease is type 2 diabetes mellitus.