Type 2 diabetes (T2D) is a multi-faceted disease, with both genetic and environmental risk factors (Kahn 2003, 2; Langenberg and Lotta 2018; Huang and Hu 2015), which is marked by impaired beta cell function; specifically, defective glucose-stimulated insulin secretion (GSIS) (American Diabetes Association 2004; Christensen and Gannon 2019; Al-Sulaiti et al. 2019). The gene discussed is INS; the disease is type 2 diabetes mellitus.