Analysis using the Enrichr tool (Kuleshov et al. 2016) showed that genes downregulated by iAsIII treatment are enriched in maturity onset diabetes of the young (MODY), T2D, insulin secretion, and calcium signaling pathways, as well as MAPK signaling and cell cycle (Supplemental Table 2). The gene discussed is INS; the disease is type 2 diabetes mellitus.