PPP4R3A and neoplasm: In addition, PPP4R3A plays an important role in the maintenance of embryonic stem cell pluripotency, hepatic gluconeogenesis, glucose metabolism, tumor suppression, tumor angiogenesis, microRNA biogenesis and transcription initiation (Yoon et al., 2010; Lyu et al., 2011; Byun et al., 2012; Dong et al., 2012; Ma et al., 2014; Su et al., 2017; Sen et al., 2020; Wang et al., 2021).