CRK and cancer: In line with our data that ACPSVs are prevalent in solid tumors and consistent with the notion that ACPSVs may play pivotal roles in tumor biogenesis and metastasis, Crk and JNK have been reported to be overexpressed in tumors, and is associated with tumorigenesis, tumor progression, and poor prognosis with reduced survival rates in many cancers, including oral squamous cell carcinoma24–29.