IL1B and chronic myelogenous leukemia, BCR-ABL1 positive: In terms of lung microbiota functionality, the abundances of four signaling pathways—Wnt (ko04310), Notch (ko04330), chronic myeloid leukemia (ko05220), and MAPK–yeast (ko04011)—were found to have strong negative correlations with serum IL-1β and IL-10 levels, indicating that these pathways might play roles in the interaction between the lung microbiota and host immunity and should be addressed in more detail in follow-up studies.