In terms of microbiota functionalities, three signaling pathways—Wnt (ko04310), Notch (ko04330), and chronic myeloid leukemia (ko05220)—had negative correlations with IL-1β levels, while the mitogen-activated protein kinase (MAPK) signaling pathway–yeast (ko04011) was negatively correlated with IL-10 levels. The gene discussed is IL10; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.