NOS1 and schizophrenia: Additionally, basic visual sensory processing differences have already been associated with two NMDA-related genes, DTNBP1 and NOS1, both implicated in schizophrenia risk103,104, and haploinsufficiency of PRODH in 22q11.2DS has been proposed as a modifier gene for schizophrenia: By modulating cortical dopaminergic transmission and glutamatergic signaling during early brain development, PRODH could influence vulnerability for schizophrenia105.