To address this, we selected five validated ARcircs and detected their expression changes upon overexpression of the wildtype or mutant form of ADAR1/2 in MB231 (breast cancer cell line), MKN28 (gastric tubular adenocarcinoma cell line), SNU398 (hepatocellular carcinoma cell line), and HCT15 (colorectal cancer cell line). This evidence concerns the gene ADAR and breast carcinoma.