Consistent with these findings, immunofluorescence analysis revealed that the fetal intestine marker Sca1 (Fig. 8i) and the adult gastric markers Tff2 (Fig. 8j), Pgc (Fig. 8k), and Gif (Fig. 8l) were robustly expressed in multiple cells in a subset of glandular structures of adenoma (mean ± SEM = 22.4 ± 3.49%, 27.7 ± 4.72%, 19.4 ± 3.92%, and 7.17 ± 2.21% of glands, respectively, n = 3 mice), similar to our findings for spatiotemporal reprogramming in regenerating normal crypts (Fig. 7). Here, MIF is linked to adenoma.