With the observed co-enhancement of FAO and CD47 in GBM prognosis and FAO-associated CD47 expression and anti-phagocytosis in RR GBM cells, we then assumed that in addition to fueling the energy demand for tumor cell survival and proliferation, the boosted FAO metabolism may offer the RR GBM cells with an immune evasion ability by protecting macrophage-mediated phagocytosis via FAO-mediated CD47 expression. The gene discussed is CD47; the disease is glioblastoma.