Indeed, processes such as the regulation of axonal functions20,33,81, cancer cell migration, invasion and metastasis31,32,82, and autophagy10,15,20,29 have all been shown to be influenced by endolysosome positioning and motility, consistent with a role for RUFY3 and RUFY4 in the regulation of endolysosomal functions. This evidence concerns the gene RUFY3 and cancer.