Furthermore, while the predictive performances achieved by ADC measures alone in this study were relatively modest, the ACRIN 6698 primary analysis demonstrated that higher AUCs could be achieved through multivariable modeling to incorporate important clinical characteristics, such as tumor HR/HER2 subtype [14], and additional consideration of other biologic factors (e.g., age, breast density, histopathology) could further improve predictive accuracy. Here, ERBB2 is linked to neoplasm.