Some contraindications are common to TNF-α inhibitors, such as multiple sclerosis and other demyelinating diseases, optic neuritis, heart failure functional class 3 or 4, active infections, untreated latent tuberculosis, previous lymphoma or current neoplasia, congenital or acquired immunodeficiency, and hypersensitivity to the formula components.3 The gene discussed is TNF; the disease is demyelinating disease.