The main adverse effects of TNF-alpha inhibitor drugs are cutaneous infusion reactions (local pruritus, pain, erythema and edema) with the subcutaneous administration of the drug and systemic reactions when the route is intravenous, with acute allergic reactions, anaphylaxis, fever or chronic reactions; cytopenias; infections, most commonly of the upper airways; autoimmunity induction; paradoxical psoriasis, among others.5 Here, TNF is linked to infection.