Cytotoxic antitumor CD8+ T cells (CTLs) recognize peptides typically of 8–10 amino acids within the MHC-I complex expressed on the cellular surface, and therefore, the knowledge of these peptides is the key to design T-cell-based therapeutic cancer vaccines; indeed, their efficacy relies mostly on the choice of the antigenic peptides (Hollingsworth and Jansen, 2019). Here, CD8A is linked to cancer.