CXCR4 and neoplasm: (A–D) The treated (right side) and untreated tumors (left side) were harvested at the end of the experiment and analyzed for the CD8+/CD4+ ratio (A) and the frequency of CD8+ (B), CD8+ CXCR4+ (C), and CD8+ CXCR3+ (D) in the tumor microenvironment (TME).