NFE2L2 and autism spectrum disorder: And, the activated Nrf2 can downregulate oxidative stress and inflammation parameters (NF-κB, IL-6, IL-1β) in autistic children, which is responsible for the ameliorative effects in Autism spectrum disorder (ASD) subjects [9], indicating Nrf2 play a significant role by its management of anti-inflammatory and antioxidant genes in arsenic-induced hepatotoxicity.