By observing the static location changes in the SOX9-positive rosette formation from fibrosis to cirrhosis, we found that the SOX9-positive rosette structure showed a gradual increase in the SOX9 expression level and changed to ductular-like structure from the periportal parenchyma to the portal region, which might imply the possibility that LPLCs differentiate to RDCs during cholestasis progression. This evidence concerns the gene SOX9 and Cirrhosis.