NOS2 and Insulin resistance: However, in obese individuals, the accumulation of macrophages in WAT increases [7] along with macrophage polarization towards the M1 phenotype, with increased expression of CD11c, inducible nitric oxide synthase (iNOS) and tumour necrosis factor (TNF)-α, promoting the inflammatory process and leading to insulin resistance in WAT [6, 8, 9].