The combination of non-invasive imaging using OCT/OCT-A to detect AD-specific alterations in retinal architecture and morphology with the detection of Aβ, tau and neurofilament light chain in the lens, vitreous and retina [304] provides compelling evidence that the eye manifests early AD-related changes that may be non-invasively detected and monitored in patients. The gene discussed is NEFL; the disease is Alzheimer disease.