Interestingly, in human primary AML cells with mutant IDH2, the same concentrations of DM-αKG (4–8 mM) did not cause any significant change in C-MYC protein (Fig. 7g), indicating a different metabolism in AML cells with mutated IDH2, which could produce 2-hydroxyglutarate to antagonize the function of α-KG. This evidence concerns the gene IDH2 and acute myeloid leukemia.