have been explored broadly, which caused vascular endothelial cell damage, release of a large number of vWF, lack of vWF-cp or inhibition of vWF-cp activity, leading to microaggregation of platelets and vWF-fibrinogen, vessel occlusion, and rapid reduction of platelets, and finally resulting in occurrence of TTP [6]. This evidence concerns the gene VWF and thrombotic thrombocytopenic purpura.