MECP2 and atypical Rett syndrome: From 2004 to 2005, two studies using real-time quantitative PCR to detect rearrangements in MECP2 found a previously undetected MECP2 duplication in: (1) a 34-year old female diagnosed with the preserved speech variant of Rett syndrome [10], and (2) an 8-year old boy [12].