Both in-vivo and in-vitro studies have shown that the upregulation of SIRT1 expression can inhibit activation of the TGF-β1/SMAD3 signaling pathway and weaken EMT, suggesting that SIRT1 plays an important role in the prevention of airway remodeling in COPD [56]. The gene discussed is SIRT1; the disease is chronic obstructive pulmonary disease.