ACE and obstructive sleep apnea syndrome: In this post hoc analysis of single-center data from the SAVE study, we found that usage of ACE inhibitors and nitrates were related to the decrease in survival in patients with comorbid OSA and cardiovascular/cerebrovascular disease; ACE inhibitors was related to the increase in mortality and secondary endpoints in the CPAP group, but not in patients with good CPAP adherence; Clopidogrel and nitrates were related with a decrease in survival in the usual care group, but not in the CPAP group.