An additional investigation into the biological function and latent pathways related to LAGE3 revealed that LAGE3 might promote tumor development in HCC via intrinsic PI3K/AKT/mTOR and Ras/RAF/MAPK pathways, the development of specific LAGE3 target drugs might become novel treatment strategies for HCC patients. This evidence concerns the gene LAGE3 and hepatocellular carcinoma.