Moreover, the IHC investigation of the LAGE3 expression in HCC tissue chips demonstrated that LAGE3 expression was relatively higher in 79 HCC cases (A1-A12, B1-B12, C1-C12, D1-D12, E1-E12, F1-F12, and G1-G7) when compared to ten cases of adjacent non-tumor liver tissue (G8-G12 and H1-H5) and six cases of normal liver tissue (H6-H11) (Fig. 1D). Here, LAGE3 is linked to hepatocellular carcinoma.