LAGE3 and hepatocellular carcinoma: Our in vitro CCK8 assay and BrdU assay study results disclosed that LAGE3 gene knockdown can reduce the proliferation of HCC as the cell cycle assay showed that the LAGE3 gene knockdown in SMCC-7721 cells arrested the cells in the S phase while the Huh7 cells in the G1 phase were arrested.