Compared with normal, the ITPR1 expression levels in ductal breast carcinoma in situ stroma, invasive ductal breast cancer stroma, ductal breast cancer, medullary breast cancer, invasive breast cancer and invasive ductal breast cancer were significantly reduced (Fig. 2A-F P= 6.40E-4, 0.003, 1.05E-7, 1.64E-11, 8.45E-12 and 2.54E-19, Supplementary Table 1). The gene discussed is ITPR1; the disease is ductal breast carcinoma in situ.