We found that the expression of ITPR1 gene is unstable in head and neck cancer, kidney cancer, leukemia, melanoma and sarcoma, but in bladder cancer, brain and central nervous system cancer, breast cancer, cervical cancer, colorectal cancer, lung cancer, lymphoma, Ovarian cancer and prostate cancer had lower expression (Fig. 1A). The gene discussed is ITPR1; the disease is central nervous system cancer.